Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients.
Fiche publication
Date publication
mars 2016
Journal
PLoS neglected tropical diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DEVILLIERS Hervé
Tous les auteurs :
Petitdemange C, Wauquier N, Devilliers H, Yssel H, Mombo I, Caron M, Nkoghé D, Debré P, Leroy E, Vieillard V
Lien Pubmed
Résumé
Dengue virus (DENV) is the most prominent arbovirus worldwide, causing major epidemics in South-East Asia, South America and Africa. In 2010, a major DENV-2 outbreak occurred in Gabon with cases of patients co-infected with chikungunya virus (CHIKV). Although the innate immune response is thought to be of primordial importance in the development and outcome of arbovirus-associated pathologies, our knowledge of the role of natural killer (NK) cells during DENV-2 infection is in its infancy.
Mots clés
Adult, Chikungunya Fever, complications, Coinfection, pathology, Dengue, complications, Female, Gabon, Humans, Killer Cells, Natural, immunology, Longitudinal Studies, Male
Référence
PLoS Negl Trop Dis. 2016 Mar;10(3):e0004499