Copeptin is an independent prognostic factor for transplant-free survival in cirrhosis.

Fiche publication


Date publication

avril 2016

Journal

Liver international : official journal of the International Association for the Study of the Liver

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DI MARTINO Vincent


Tous les auteurs :
Kerbert AJ, Weil D, Verspaget HW, Moréno JP, van Hoek B, Cervoni JP, Di Martino V, Coenraad MJ, Thevenot T

Résumé

Copeptin is a stable cleavage product of the arginine vasopressin (AVP) precursor and is equimolarly secreted with AVP. Copeptin is currently considered a reliable prognostic marker in a wide variety of diseases other than cirrhosis. We aimed to investigate the association between severity of cirrhosis and copeptin concentrations and to confirm whether copeptin is of prognostic significance in cirrhosis.

Mots clés

Adult, Aged, Biomarkers, blood, Chi-Square Distribution, Decision Support Techniques, Disease-Free Survival, Female, France, Glycopeptides, blood, Hospitalization, Humans, Kaplan-Meier Estimate, Liver Cirrhosis, blood, Liver Transplantation, Male, Middle Aged, Multivariate Analysis, Netherlands, Predictive Value of Tests, Proportional Hazards Models, Risk Factors, Severity of Illness Index, Tertiary Care Centers, Time Factors, Up-Regulation

Référence

Liver Int.. 2016 Apr;36(4):530-7