Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer.
Fiche publication
Date publication
décembre 2019
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MATHELIN Carole, Dr NOBLET Vincent
Tous les auteurs :
Moliere S, Oddou I, Noblet V, Veillon F, Mathelin C
Lien Pubmed
Résumé
Breast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and its prognostic value to predict recurrence. MRI BPE was visually and quantitatively evaluated before and after NAC in a retrospective cohort of 102 women with unilateral biopsy-proven invasive breast cancer. Pre-therapeutic BPE was not predictive of pathological response or recurrence. Quantitative post-therapeutic BPE was significantly decreased compared to pre-therapeutic value. Post-therapeutic quantitative BPE significantly predicted recurrence (HR = 6.38 (0.71, 12.06), p < 0.05).
Référence
Sci Rep. 2019 Dec 16;9(1):19185