The microenvironment controls invadosome plasticity.
Fiche publication
Date publication
mai 2016
Journal
Journal of cell science
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky
Tous les auteurs :
Di Martino J, Henriet E, Ezzoukhry Z, Goetz JG, Moreau V, Saltel F
Lien Pubmed
Résumé
Invadosomes are actin-based structures involved in extracellular matrix degradation. Invadosomes is a term that includes podosomes and invadopodia, which decorate normal and tumour cells, respectively. They are mainly organised into dots or rosettes, and podosomes and invadopodia are often compared and contrasted. Various internal or external stimuli have been shown to induce their formation and/or activity. In this Commentary, we address the impact of the microenvironment and the role of matrix receptors on the formation, and dynamic and degradative activities of invadosomes. In particular, we highlight recent findings regarding the role of type I collagen fibrils in inducing the formation of a new linear organisation of invadosomes. We will also discuss invadosome plasticity more generally and emphasise its physio-pathological relevance.
Mots clés
Actins, metabolism, Animals, Cellular Microenvironment, physiology, Collagen Type I, metabolism, Exosomes, metabolism, Extracellular Matrix, metabolism, Humans
Référence
J. Cell. Sci.. 2016 05 1;129(9):1759-68