The role of heparan sulfate maturation in cancer: a focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs).

Fiche publication


Date publication

novembre 2019

Journal

Seminars in cancer biology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr FOURNEL-GIGLEUX Sylvie, Dr GULBERTI Sandrine


Tous les auteurs :
Gulberti S, Mao X, Bui C, Fournel-Gigleux S

Résumé

Heparan-sulfate modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of HS binding proteins, including growth factors and chemokines, morphogens and immunity cell receptors. This review will highlight the importance of HS maturation mediated by N-deactetylase/sulfotransferases, 2- and 6O-sulfotransferases in cancer biology, and will focus on the 3O-sulfotransferases and on the terminal, rare 3O-sulfation, and their important but still enigmatic impact in cancer progression. The review will also discuss the molecular mechanisms of action of these HS modifications with regards to ligand interactions and signaling in the cancer process and their clinical significance.

Mots clés

3O-sulfation, cancer, heparan sulfate, heparan sulfate binding proteins, sulfotransferases

Référence

Semin. Cancer Biol.. 2019 Nov 8;: