Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer's Disease: Clinical and FDG-PET Correlation.
Fiche publication
Date publication
septembre 2019
Journal
Journal of Alzheimer's disease : JAD
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen, Dr GOBBO Jessica
Tous les auteurs :
Chanteloup G, Cordonnier M, Moreno-Ramos T, Pytel V, Matías-Guiu J, Gobbo J, Cabrera-Martín MN, Gómez-Pinedo U, Garrido C, Matías-Guiu JA
Lien Pubmed
Résumé
We aimed to study the expression of circulating heat-shock protein HSP70 and exosomes in plasma of a cohort of patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) at different stages. We performed correlations with clinical scales and FDG-PET. HSP70 levels were higher within exosomes than free in plasma. Moderate correlations were found between exosomal HSP70 and CDR, FTLD-CDR, and extension of hypometabolism. Our results suggest modifications in the level of exosomal HSP70 during the course of neurodegeneration, regardless of AD or FTD, and therefore HSP70 could have a potential role in the follow-up of these disorders.
Mots clés
Alzheimer’s disease, PET, biomarkers, exosomes, frontotemporal dementia
Référence
J. Alzheimers Dis.. 2019 Sep 3;: