Extracellular Vesicles: Catching the Light in Zebrafish.
Fiche publication
Date publication
août 2019
Journal
Trends in cell biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOETZ Jacky, Dr HYENNE Vincent
Tous les auteurs :
Verweij FJ, Hyenne V, Van Niel G, Goetz JG
Lien Pubmed
Résumé
Extracellular vesicles (EVs) circulate in the body fluids of all organisms where they participate in intercellular cross-organ communication. Tracking and understanding these nanosized objects has been hampered by the low resolution of imaging techniques and by the lack of appropriate animal models. The use of zebrafish embryos permits visualization of EVs at unprecedented spatiotemporal resolution using light and electron microscopy. This enables the study of endogenous physiological EVs and pathological EVs side by side, and further unravels their mechanisms of biogenesis, biodistribution, and target cells throughout the organism. These developments will contribute to a better understanding of the in vivo (patho)physiology of EVs.
Mots clés
circulation, exosomes, extracellular vesicles, high-resolution imaging, in vivo, zebrafish
Référence
Trends Cell Biol.. 2019 Aug 7;: