Portal hypertension with extensive fibrosis and plasma cell infiltration in multiple myeloma.
Fiche publication
Date publication
décembre 2016
Journal
Clinics and research in hepatology and gastroenterology
Auteurs
Lien Pubmed
Résumé
Plasma cell infiltration of the liver has been described in about 45% of patient with multiple myeloma in autopsy review; however, it is usually not associated with significant liver dysfunction. Indeed, only rare cases of massive plasma cell infiltration leading to non-obstructive cholestasis and hepatic failure have been described. Here, we report a case with a history of 8 years of MM with extensive liver fibrosis and portal hypertension with no other evidence aetiology unless massive plasma cell infiltration who presented a significant regression of both biological liver abnormalities and liver stiffness after ten months of chemotherapy concomitantly to a significant decrease of the IgG serum monoclonal band.
Référence
Clin Res Hepatol Gastroenterol. 2016 Dec;40(6):e71-e73