Epidermal growth factor receptor mutations are linked to skip N2 lymph node metastasis in resected non-small-cell lung cancer adenocarcinomas†.
Fiche publication
Date publication
décembre 2016
Journal
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEAU-FALLER Michèle, Pr FALCOZ Pierre-Emmanuel
Tous les auteurs :
Guerrera F, Renaud S, Tabbó F, Voegeli' AC, Filosso PL, Legrain M, Boita M, Schaeffer M, Beau-Faller M, Ruffini E, Falcoz PE, Inghirami G, Oliaro A, Massard G
Lien Pubmed
Résumé
The impact of skip N2 metastases (i.e. N2 lymph node metastases without N1) on survival in surgically resected non-small lung cancer remains an intriguing and rarely investigated topic. The goal of our study was to elucidate (i) skip N2 influence on overall survival (OS) and time to recurrence (TTR) in patients with resected lung adenocarcinoma and (ii) its link with epidermal growth factor receptor ( EGFR ) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutations.
Référence
Eur J Cardiothorac Surg. 2016 Dec;: