Cytotoxic glycosides from the roots of Weigela x "Bristol Ruby".
Fiche publication
Date publication
juin 2019
Journal
Fitoterapia
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COLLIN Bertrand, Dr BELLAYE Pierre-Simon
Tous les auteurs :
Nguyen DH, Mitaine-Offer AC, Maroso S, Papini AM, Paululat T, Bellaye PS, Collin B, Chambin O, Lacaille-Dubois MA
Lien Pubmed
Résumé
Seven oleanane-type glycosides were extracted and isolated by various chromatographic methods from the roots of Weigela x "Bristol Ruby" (1-7), six previously undescribed (1-6) and a known one (7). Their structures were assigned by spectroscopic analysis mainly 2D NMR and mass spectrometry (ESIMS). Selected triterpenoid glycosides (1-3, 6, 7) displayed a good cytotoxic activity against a mouse colon cancer cell line CT26.
Mots clés
Caprifoliaceae, Cytotoxicity, NMR, Oleanolic acid glycosides, Weigela x “Bristol Ruby”
Référence
Fitoterapia. 2019 Jun 13;:104242