Carriage of a single strain of non-toxigenic biovar Belfanti () in four patients with cystic fibrosis.

Fiche publication


Date publication

février 2019

Journal

Journal of clinical microbiology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HUET Frédéric


Tous les auteurs :
Pivot D, Fanton A, Badell-Ocando E, Benouachkou M, Astruc K, Huet F, Amoureux L, Neuwirth C, Criscuolo A, Aho S, Toubiana J, Brisse S

Résumé

Cystic fibrosis (CF) patients are commonly colonized by bacterial pathogens, which can induce persistent lung inflammation and may contribute to clinical deterioration. Colonization of CF patients and cross-transmission by has not been reported so far. The aim of this article was to investigate the possibility of a cross transmission of biovar Belfanti between four patients of a CF center. biovar belfanti (now formally called ) isolates were collected from four patients in a single CF care center over a 6 years period and analyzed by microbiological methods and whole genome sequencing. Epidemiological links among patients were investigated. Ten isolates were collected from 4 patients. Whole genome sequencing of one isolate from each patient showed that a single strain was shared among them. In addition, one patient had the same strain on two consecutive samplings nine months apart. The strain was non-toxigenic and was susceptible to most antimicrobial agents. Ciprofloxacin resistance was observed in one patient. Transmission of the strain among patients was supported by the occurrence of same-day visits to the CF center. This study demonstrates colonization of CF patients by biovar Belfanti () and suggests persistence and transmission of a unique strain during at least six years in a single CF patient care center.

Référence

J. Clin. Microbiol.. 2019 Feb 27;: