The variability of hepatitis B envelope is associated with HBs antigen persistence in either chronic or acute HBV genotype A infection.
Fiche publication
Date publication
août 2017
Journal
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BRONOWICKI Jean-Pierre, Dr JEULIN Hélène
Tous les auteurs :
Eschlimann M, Malvé B, Velay A, Fenaux H, Berger S, Frippiat JP, Zoulim F, Bensenane M, Bronowicki JP, Goehringer F, May T, Jeulin H, Schvoerer E
Lien Pubmed
Résumé
More than 240 million people are chronically infected by hepatitis B virus (HBV) worldwide. Envelope proteins play a crucial role in viral cellular entry and immune recognition. The loss of HBs antigen (HBsAg) correlated with a good clinical prognosis is rarely achieved with or without treatment (3-16%).
Mots clés
Deletions, HBV preS/S variability, HBV/HIV coinfection, Hepatitis B virus, Immune escape
Référence
J. Clin. Virol.. 2017 Aug;94:115-122