Microbiota in digestive cancers: our new partner?

Fiche publication


Date publication

août 2017

Journal

Carcinogenesis

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BRONOWICKI Jean-Pierre


Tous les auteurs :
Lopez A, Hansmannel F, Kokten T, Bronowicki JP, Melhem H, Sokol H, Peyrin-Biroulet L

Résumé

Evolution led to an essential symbiotic relationship between the host and commensal microbiota, regulating physiological functions including inflammation and immunity. This equilibrium can be disturbed by environmental factors such as lifestyle, diet or antibiotic pressure, contributing to create a dysbiosis. There is much evidence about the gut microbiota's contribution to carcinogenesis, involving proinflammatory and immunosuppressive signals. At the same time, it seems increasingly clear that commensal microbes can modulate cancer therapy efficacy and safety, in particular innovating treatments as immune checkpoint inhibitors. In this review, we discuss how the microbiota can promote digestive tract carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.

Mots clés

Animals, Dysbiosis, complications, Gastrointestinal Microbiome, Gastrointestinal Neoplasms, microbiology, Humans

Référence

Carcinogenesis. 2017 Aug;: