Antitumor Effects of Lidocaine on Human Breast Cancer Cells: An and Experimental Trial.
Fiche publication
Date publication
janvier 2018
Journal
Anticancer research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MATHELIN Carole, Dr TOMASETTO Catherine
Tous les auteurs :
Chamaraux-Tran TN, Mathelin C, Aprahamian M, Joshi GP, Tomasetto C, Diemunsch P, Akladios C
Lien Pubmed
Résumé
Retrospective studies have suggested a protective effect of regional anesthesia against recurrence after cancer surgery. But confirmation of the in vivo antitumor effects is lacking. We examined the in vitro antitumor effects of lidocaine on various breast cancer cell lines and then assessed these properties in vivo at clinically relevant concentrations.
Mots clés
Anesthetics, Local, pharmacology, Animals, Antineoplastic Agents, pharmacology, Breast Neoplasms, drug therapy, Cell Line, Tumor, Cell Movement, drug effects, Cell Survival, drug effects, Female, Humans, Lidocaine, pharmacology, Mice, SCID, Peritoneal Neoplasms, drug therapy
Référence
Anticancer Res.. 2018 01;38(1):95-105