Nlrp3 Gene Expression in Circulating Leukocytes Declines During Healthy Aging.

Fiche publication


Date publication

février 2018

Journal

The journals of gerontology. Series A, Biological sciences and medical sciences

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FAIVRE Béatrice, Dr RIALLAND Mickaël


Tous les auteurs :
Connat JL, Dumont A, Rialland M, Faivre B, Sorci G

Résumé

Aging is often associated with elevated levels of low grade inflammation supposed to drive age-associated diseases. Here, we conducted a cross-sectional study on 58 healthy volunteers, aged from 19 to 81, to investigate the relationship between age and the expression of three inflammasome component genes (Nlrp3, Asc, Casp1), the up-stream transcription factor NFkB, and the pro-inflammatory cytokine Il-1 in leukocytes. We also assessed C-reactive protein (CRP) and IL-1 in plasma, as additional inflammatory markers. We did not find any support to the hypothesis that inflammasone activation increases with age. Expression of Asc, Casp1, NFkB and Il-1 did not vary with age, body mass index, and CRP levels. In addition, expression did not differ between males and females or between smokers and non-smokers. A notable exception was the expression of Nlrp3 which varied non-linearly with age. Specifically, Nlrp3 expression strongly declined during aging, in subjects who were between 50 and 81 years old. CRP was higher in women and increased as a function of age-corrected body mass index, while only four subjects showed detectable amount of IL-1 in plasma. Further work on larger cohorts with a longitudinal monitoring should be conducted to corroborate the finding that healthy aging is associated with a decrease in inflammasome activation.

Référence

J. Gerontol. A Biol. Sci. Med. Sci.. 2018 Feb 3;: