De-escalating systemic therapy in triple negative breast cancer: The example of secretory carcinoma.
Fiche publication
Date publication
avril 2018
Journal
Journal of gynecology obstetrics and human reproduction
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MATHELIN Carole
Tous les auteurs :
Benabu JC, Stoll F, Koch A, Molière S, Bellocq JP, Mathelin C
Lien Pubmed
Résumé
Triple negative breast cancers have the highest relapse risk and the least favourable prognosis of all breast cancer subtypes, leading to an escalation of chemotherapy, substantially during recent years. Secretory carcinoma of the breast is a rare triple negative neoplasm, first described in children but more often presenting in adults. We report a case of a 70-years-old woman, initially diagnosed on the biopsy with a triple negative infiltrating Not Otherwise Specified (NOS) carcinoma of the breast, before it was later correctly identified as a secretory carcinoma, notably because of an abundant intra and extracellular secretory material. This new diagnosis, confirmed by fluorescence in-situ hybridization analysis showing ETS variant 6 (ETV6) gene rearrangement, allowed the de-escalation of chemotherapy therapy. Four years later, the patient is free of recurrences.
Mots clés
De-escalation, Juvenile breast carcinoma, Secretory breast carcinoma, Triple-negative breast carcinoma
Référence
J Gynecol Obstet Hum Reprod. 2018 Apr;47(4):163-165