Effect of Carbidopa on 18F-FDOPA Uptake in Insulinoma: From Cell Culture to Small-Animal PET Imaging.
Fiche publication
Date publication
janvier 2017
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRASSE David, Pr NAMER Izzie-Jacques
Tous les auteurs :
Detour J, Pierre A, Boisson F, Kreutter G, Lavaux T, Namer IJ, Kessler L, Brasse D, Marchand P, Imperiale A
Lien Pubmed
Résumé
Patient premedication with carbidopa seems to improve the accuracy of 6-(18)F-fluoro-3,4-dihydroxy-l-phenylalanine ((18)F-FDOPA) PET for insulinoma diagnosis. However, the risk of PET false-negative results in the presence of carbidopa is a concern. Consequently, we aimed to evaluate the effect of carbidopa on (18)F-FDOPA uptake in insulinoma β-cells and an insulinoma xenograft model in mice.
Mots clés
18F-FDOPA, PET, RIN-m5F, carbidopa, insulinoma, small-animal PET
Référence
J. Nucl. Med.. 2017 Jan;58(1):36-41