The Human Cytomegalovirus Strain DB Activates Oncogenic Pathways in Mammary Epithelial Cells.
Fiche publication
Date publication
avril 2018
Journal
EBioMedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier, Pr HERBEIN Georges
Tous les auteurs :
Kumar A, Tripathy MK, Pasquereau S, Al Moussawi F, Abbas W, Coquard L, Khan KA, Russo L, Algros MP, Valmary-Degano S, Adotevi O, Morot-Bizot S, Herbein G
Lien Pubmed
Résumé
Human cytomegalovirus (HCMV) establishes a persistent life-long infection and increasing evidence indicates HCMV infection can modulate signaling pathways associated with oncogenesis. Breast milk is an important route of HCMV transmission in humans and we hypothesized that mammary epithelial cells could be one of the main cellular targets of HCMV infection.
Mots clés
CTH cells, Cytomegalovirus, HCMV, HCMV-DB, HMECs, Oncogenesis, Transformation, lncRNA4.9
Référence
EBioMedicine. 2018 Apr;30:167-183