LRP1 expression in colon cancer predicts clinical outcome.

Fiche publication


Date publication

février 2018

Journal

Oncotarget

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BOUCHE Olivier, Pr DEDIEU Stéphane, Dr BOULAGNON-ROMBI Camille, Dr SCHNEIDER Christophe, Pr LEBRE Anne-Sophie, Dr NASRI Saviz


Tous les auteurs :
Boulagnon-Rombi C, Schneider C, Leandri C, Jeanne A, Grybek V, Bressenot AM, Barbe C, Marquet B, Nasri S, Coquelet C, Fichel C, Bouland N, Bonnomet A, Kianmanesh R, Lebre AS, Bouché O, Diebold MD, Bellon G, Dedieu S

Résumé

LRP1 (low-density lipoprotein receptor-related protein 1), a multifunctional endocytic receptor, has recently been identified as a hub within a biomarker network for multi-cancer clinical outcome prediction. As its role in colon cancer has not yet been characterized, we here investigate the relationship between LRP1 and outcome.

Mots clés

BRAF, LRP1, Pathology, colorectal cancer, miR-205, microsatellite instability

Référence

Oncotarget. 2018 Feb 6;9(10):8849-8869