Constitutive NF-kappaB activity influences basal apoptosis and radiosensitivity of head-and-neck carcinoma cell lines.
Fiche publication
Date publication
décembre 2001
Journal
International journal of radiation oncology, biology, physics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BARBERI-HEYOB Muriel, Pr MERLIN Jean-Louis, Dr MIRJOLET Céline
Tous les auteurs :
Didelot C, Barberi-Heyob M, Bianchi A, Becuwe P, Mirjolet JF, Dauça M, Merlin JL
Lien Pubmed
Résumé
Nuclear factor-kappaB (NF-kappaB) has been implicated in anti-apoptotic gene transactivation, according to its transcriptional activity. The present study was designed to investigate whether constitutive NF-kappaB activity could modulate basal apoptosis and intrinsic radiosensitivity of KB head-and-neck carcinoma cell line and KB3 subline. The KB3 subline was more radiosensitive (SF2 = 0.48, alpha = 0.064) than the radioresistant KB parental cell line (SF2 = 0.80, alpha = 0.114).
Mots clés
Apoptosis, DNA, metabolism, Head and Neck Neoplasms, pathology, Humans, NF-kappa B, physiology, Radiation Tolerance, Tumor Cells, Cultured
Référence
Int. J. Radiat. Oncol. Biol. Phys.. 2001 Dec;51(5):1354-60