Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha.

Fiche publication


Date publication

novembre 2004

Auteurs

Membres identifiés du Cancéropôle Est :
Dr FREUND Jean-Noël


Tous les auteurs :
Wang L, Klopot A, Freund JN, Dowling LN, Krasinski SD, Fleet JC

Résumé

Calbindin D9k (CaBP) is critical for intestinal calcium absorption; its in vivo expression is restricted to differentiated enterocytes of the small intestine. Our goal was to identify factors controlling the transcriptional regulation of this gene in the human intestine. Both the natural gene and a 4600-bp promoter construct were strongly regulated by differentiation (>100-fold) but not by treatment with 1,25(OH)2 vitamin D (

Référence

Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G943-53