[Phenotypic and functional analysis of T lymphocytes in cancer patients]
Fiche publication
Date publication
juin 2005
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier
Tous les auteurs :
Badoual C, Vingert B, Agueznay N, Adotevi O, Haicheur N, Molina T, Bruneval P, Fridman WH, Tartour E
Lien Pubmed
Résumé
In preclinical tumor model and in human cancer, tumor antigen specific T lymphocytes play a key role in the control of tumor development. Nevertheless in numerous cases, the infiltrating tumor T cells do not seem to influence the clinical progression of the tumor. A better phenotypic and functional characterization of T cells in close contact with tumor associated with a comprehensive analysis of tumor evasion mechanism to the host response should lead to an optimization of cancer immunotherapy protocols.
Référence
Ann Pathol. 2005 Jun;25(3):211-9.