Precise localization of sentinel lymph nodes and estimation of their depth using a prototype intraoperative mini gamma-camera in patients with breast cancer
Fiche publication
Date publication
avril 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MATHELIN Carole
Tous les auteurs :
Mathelin C, Salvador S, Huss D, Guyonnet JL
Lien Pubmed
Résumé
The aim of this study was to evaluate the ability of a prototype intraoperative mini gamma-camera, the CarollReS, with a 50 x 50 mm field of view, to precisely localize sentinel lymph nodes (SLNs) and to cleterminetheir depth in a series of patients with infiltrative breast cancer requiring SLN excision. Methods: With the use of phantoms, the broadness of the signal of an acquired projection was shown to linearly depend on its distance from the collimator. A preclinical ex vivo study of 25 excised SLNs demonstrated that SLN size did not influence depth estimation. The minimum activity threshold for successful use of the proposed method was determined. After a preoperative radioisotope injection and lymphoscintigraphy, the SLN was localized in a series of 11 patients using both the mini gamma-camera and ay-probe. During surgery, a ruler was used to measure the depth of all SLNs before their excision. Results: Using the measured linear dependence of image broadness, we found that the expected SLN anatomic depth was compatible with its measured depth during surgery. Conclusion: This study showed that the mini gamma-camera efficiently estimated the location of SLNs in 3 dimensions.
Référence
J Nucl Med. 2007 Apr;48(4):623-9.