Polyelectrolyte films boost progenitor cell differentiation into endothelium-like monolayers
Fiche publication
Date publication
juillet 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VOEGEL Jean-Claude, Pr MENU Patrick, Pr SCHAAF Pierre, Dr KERDJOUDJ Halima
Tous les auteurs :
Berthelemy N, Kerdjoudj H, Gaucher C, Schaaf P, Stolz JF, Lacolley P, Voegel JC, Menu P
Lien Pubmed
Résumé
Rapid differentiation of endothelial progenitor cells (EPCs) into confluent mature endothelial cells (see figure) is important in tissue engineering for the design of autologous, nonthrombotic, vascular grafts. A new method based on EPC culture on poly(sodium-4styrene-sulfonate)/poly(allylamine hydrochloride), that is, polyelectrolyte-multilayer-coated substrates, reduces the time from two months to two weeks.
Référence
Adv Mater. 2008 Jul 17;20(14):2674-+