[Merkel cell carcinoma, role of radiotherapy and literature review]

Fiche publication


Date publication

janvier 2009

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GUIHARD Sébastien, Pr NOEL Georges


Tous les auteurs :
Guihard S, Noel G

Résumé

Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin with features of epithelial differentiation. It occurs in older patients, appears on sun exposed areas and its incidence is increasing. The surgical excision with negative margins is the first treatment and adjuvant local irradiation now is well established but regional adjuvant (lymph nodes dissection or radiation therapy) remains discussed. MCC is chemosensitive but rarely chemocurable in patients with metastasis or locally advanced tumors. The most used therapy is platinum-based polychemotherapy.

Référence

Cancer Radiother. 2009 Jan;13(1):47-54