Prognostic value of C-reactive protein levels in patients with cirrhosis.
Fiche publication
Date publication
février 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DI MARTINO Vincent
Tous les auteurs :
DI Martino V, Coutris C, Cervoni JP, Dritsas S, Weil D, Richou C, Vanlemmens C, Thevenot T
Lien Pubmed
Résumé
Identifying cirrhosis with poor short-term prognosis remains crucial to improve the allocation of liver grafts. The purpose of this study was to assess the prognostic value of a model combining the variation of CRP levels within 15 days, the MELD score and the presence of comorbidities in decompensated cirrhotic patients with Child-Pugh>B7 and to test the relevance of this model in compensated cirrhotic patients. Data of cirrhotic patients without hepatocellular carcinoma, extrahepatic malignancy, HIV infection, organ transplantation, seen between January 2010 and December 2011 were collected. Multivariate analyses of predictors of 3-months mortality used Cox models adjusted on the Age-ajusted Charlson Comorbidity Index (ACCI). The prognostic performance (AUROCs) of the 3-variables model was compared to that of the MELD score. 241 patients met the inclusion criteria, including 109 patients with Child-Pugh>B7 hospitalized for decompensation. In these severe patients, the 3-month mortality was independently predicted by the MELD (HR=1.10, 95%CI:1.05-1.14, p32mg/L at baseline and day-15 (HR=2.21, 95%CI:1.03-4.76, p=0.042). This model was better than the MELD alone (AUROC, 0.789 vs.0.734, p
Référence
Liver Transpl. 2015 Feb 11